Zvinoenderana nehuwandu hweZhiliwo Big Data Platform, avhareji yemhedzisiro yekutaura mapepa eForegene SCI muna Kukadzi 2022 yakakwira kusvika 5.8, uye yakanyanya kukanganisa chinhu i8.947.
Kuburikidza nekuongororwa kwehuwandu hwehuwandu hweSCI mapepa eForegene zvigadzirwa mumakore apfuura, zvinoonekwa kuti kukura kuri pachena.
Foregene Co., Ltd. yakavambwa muna 2011. Ibhizimusi rebiotechnology rinobatanidza R&D, kugadzira, kutengesa uye basa revatengi.Kubva payakavambwa, yanga ichitarisa mukuvandudzwa kwemamorekuru uye masero biology ane hukama matekinoroji, zvigadzirwa nemasevhisi, uye inopa nucleic acid kucheneswa, kuona nucleic acid uye dzimwe mhinduro kune ruzhinji rwevashandisi.Yayo sainzi yekutsvagisa chigadzirwa mutsara unosanganisira RNA yekuchenesa nhevedzano, DNA yekuchenesa nhevedzano, RT/RT-PCR nhevedzano, yakananga PCR yakatevedzana, PCR Mix yakatevedzana, yakananga RT-qPCR nhevedzano uye "Sui" akatevedzana mamorekuru ane hukama zviridzwa.Zvigadzirwa zvakashandiswa zvakanyanya mukutsvagisa kwekutanga muminda yehupenyu sainzi, mushonga, zvekurima, zvemishonga, uye zvakatipoteredza.Vatengi vari mumayunivhesiti, masangano ekutsvagisa, zvipatara uye zvimwe zvikamu.
ZhiLiaowo asarudza magwaro matanhatu epamusoro-soro eForegene muna Kukadzi kuti ataure nevaongorori, kuitira kuti ave nekunzwisisa kwakadzama uye kujairana neForegene zvigadzirwa.
Musoro wechinyorwa: Kuomarara kweSubstrate kunodzora kupatsanurwa kweiyo induced pluripotent stem masero mukati memoyo valve endothelial masero.
DOI: 10.1016/j.actbio.2022.02.032
Nguva yekuburitsa: 2022-2-27
Foregene
Literature Cited Products
Musoro weChinyorwa: Kuziva Inogona Kuitika Mitochondrial Proteome Siginecha Yakabatana nePathogenesis yePulmonary Arterial Hypertension muRat Model.
DOI: 10.1155/2022/8401924
Nguva yekuburitsa: 2022-2-21
Author Affiliation: Dhipatimendi re Pharmacy, Chekutanga Affiliated Hospital ye Xinjiang Medical University.
Abstract: Pulmonary arterial hypertension (PAH) chirwere chakakomba uye chinofambira mberi chinokanganisa mwoyo nemapapu uye idambudziko rehutano repasi rose rinobata vanhu nenzanga.Muchidzidzo ichi, rat modhi yePAH yakakonzerwa ne monocrotaline (MCT) yakagadzirwa zvinobudirira.Mapuroteni emitochondrial eboka rega rega remakonzo akatemerwa nekushandisa label-free quantitative proteomic techniques.Kubva pakuvaka uye kushanda kwekusimudzira kweprotein-protein interaction (PPI) network, 19 up-regulated mitochondrial genes uye 123 pasi-regulated mitochondrial majini akaongororwa mumakonzo ePAH.Pamusoro pezvo, mune yakazvimirira cohort dataset kuyedza, mhedzisiro yakaratidza kuti 6 kumusoro-inodzorwa mitochondrial genes uye 3 pasi-inodzorwa mitochondrial majini akanyatso kuratidzwa mumutsara wemapapu emakonzo ePAH.Ingangove miRNA-yakanangwa yepakati mitochondrial majini yakafanotaurwa padanho rekunyora uchishandisa iyo RNAInter dhatabhesi.Chidzidzo chacho chakaratidzawo bortezomib uye carfilzomib semishonga inogona kushandiswa pakurapa PAH.Chekupedzisira, chidzidzo ichi chinoburitsa mwenje mutsva pane akakosha biomarkers uye nzira dzekurapa dzePAHs.
Foregene
Literature Cited Products
RT Easy II (Master Premix Yekutanga Strand cDNA Synthesis YeqPCR)
Catalog Nhamba: RT-01021
Tsanangudzo: 50 × 10 μL rxns
Musoro weChinyorwa: PTEN kurasikirwa kunopa kunzwa kune rapalogs mune yakajeka cell renal cell carcinoma
DOI: 10.1038/s41401-022-00862-1
Nguva yekuburitsa: 2022-2-14
Munyori Kubatanidzwa: Dhipatimendi rePharmacy, Nanfang Hospital, Southern Medical University, Guangzhou, China
Abstract: Rapalog is allosteric mTORC1 inhibitor uye mushonga unotenderwa we advanced clear cell renal cell carcinoma (ccRCC).Zvidzidzo zvinoshandisa mitsara yakawanda inotorwa nemurwere ccRCC masero inoratidza kuti PTEN-yakashomeka maseru anoratidza hypersensitivity kune rapalogs.MuPTEN-inoshaya ccRCC cell mitsara, Rapalogs inhibited cell proliferation nekuita kuti G0/G1 kusungwa pasina kuita apoptosis.Kushandisa CRISPR/Cas9-yakagadzirwa isogenic cell lines, chidzidzo chakasimbisa kushamwaridzana pakati pePTEN kubviswa uye Rapallo hypersensitivity.Kusiyana neizvi, kubviswa kweVHL kana chromatin-modifying genes (PBRM1, SETD2, BAP1, kana KDM5C) hakuna kukanganisa mhinduro dzeserura kumarapalogs.Ectopic expression of an activated mTOR mutant (C1483F) yakaratidzwa kurwisa PTEN-induced cell growth inhibition, nepo kuunzwa kwemishonga isingagadzirisi mTOR mutant (A2034V) yakabvumira PTEN-inoshaya ccRCC maseru kutiza kukura-kudzvinyirira mhedzisiro yerapalogs.PTEN-inoshaya ccRCC masero ainyanya kutarisisa kune inhibitory mhedzisiro ye temsirolimus pa cell migration uye bundu kukura mu zebrafish uye xenograft mice.Zvidzidzo zvakaratidza kuti PTEN kubviswa kwakabatana ne rapallo senitivity uye inogona kushandiswa sechiratidzo chekusarudzwa kwerapallo therapy mu ccRCC varwere.
Foregene
Literature Cited Products
Musoro wechinyorwa: Dynamic mashandiro eiyo microbiota yemvura yakasviba yakakwira-munyu ine mbiriso inobvumira munyu uye kushandiswa kwayo.
DOI: 10.1016/j.jece.2022.107377
Nguva yekuburitsa: 2022-2-12
Munyori chikwata: Chikoro cheHupenyu Sayenzi, Jiangxi Normal University
Abstract: Yakakwira salinity organic wastewater imvura yetsvina yemumaindasitiri ine zvinhu zvakaomarara, kuderera kwe biodegradability uye yakaoma biochemical kurapwa.Kuitira kuburitsa maitiro emukati menharaunda yehutachiona mukurapwa kwemvura ine munyu yakawanda nembiriso isingatenderi munyu, zvidzidzo zvehunhu hwenharaunda yehutachiona uye zvakatipoteredza zvakaitwa.Kubviswa kwemakemikari kudiwa kweokisijeni, NH3-H uye yakazara nitrogen yakagadziridzwa zvakanyanya muyero yeWWTP.Yakakwira-kuburikidza kutevedzana mhedzisiro yakaratidza kuti biofortification yakakanganisa zvakanyanya microbial nharaunda chimiro.Pachikamu chephylum, mapoka eProteobacteria neAscomycota anotungamira, nepo padanho re genus mapoka eParacoccus neMeyeroi anotungamira.Meyerella inobata basa rakakosha mukurapa kwemvura yakasviba yemunyu yakawanda, inogona kunge iri chikonzero chikuru chekuvandudzwa kwekubvisa tsvina.Pamusoro pezvo, pH, okisijeni yakanyungudika, uye vhoriyamu ine simba ndizvo zvinhu zvakakosha zvinokanganisa kutevedzana kwenharaunda dzehutachiona panguva ye bioaugmentation, zvisinei, Meyerrotheca kuwanda haina kukanganiswa nekukanganisa kusvibiswa kwemhepo.Chidzidzo ichi chakanyatsoratidza shanduko ine simba uye fungidziro inoshanda yehutachiona panguva ye bioaugmentation, pamwe nehukama pakati penharaunda dzine hutachiona uye zvakatipoteredza, ichiisa hwaro hwakasimba hwedzidziso yekuzotevera kurapwa kwemvura yakakwira-yakawanda uye ine munyu wakawanda.
Foregene
Literature Cited Products
Musoro weChinyorwa: Multi-Omics Analysis After Vaginal Administration yeBacteroides fragilis muHuku.
DOI: 10.3389/fmicb.2022.846011
Nguva yekuburitsa: 2022-2-16
Kudyidzana nemunyori: Sichuan Key Laboratory yeKurima neMhuka Genetic Resources Development uye Innovation
Abstract: Kubereka kwehuku inhengo yakakosha pakuumbwa kwemazai.Kubatana kwepedyo pakati pemukadzi uye nharaunda yekunze kunogona kutungamirira kukupinda kwemabhakitiriya akasiyana-siyana epathogenic, kukanganisa mukati uye kunze kwehutano hwemazai, uye kunyange kuwedzera huwandu hwekufa uye kukonzera kurasikirwa kwehupfumi.Mumakore achangopfuura, maprobiotics akaunza hupfumi kune zvipfuyo nehuku kugadzirwa seimwe nzira yemishonga inorwisa mabhakitiriya.Migumisiro yekushandiswa kwechikadzi yeB. fragilis pahuku cloacal microbiota, vaginal transcriptome uye metabolome yakaongororwa kuti iongorore mikana inobatsira yeB. fragilis.Zvigumisiro zvakaratidza kuti B. fragilis kurapwa kwakakanganisa microbial kuumbwa kwe cloaca.Ongororo yeTranscriptome yakawana kuti majini ane chekuita nekudzivirira CCN3, HAS2, uye RICTOR aive akakwira-akagadziriswa, uye magene ekuputika EDNRB, TOX, uye NKX2-3 aive akadzikiswa, uye maDEG akagadziridzwawo mukutonga kwekuzvimba, cellular metabolism, uye synaptic mhinduro nzira.Pamusoro pezvo, mametabolites akasiyana ainyanya kuenderana nesteroid hormone biosynthesis, unsaturated fatty acid biosynthesis, uye arachidonic acid metabolism, uye zvidzidzo zvakaratidza kushamwaridzana pakati pematabolites akasiyana uye majini.Mukupedzisa, chidzidzo ichi chinopa hwaro hwedzidziso hwekushandiswa kweB. fragilis senge probiotic inogona kuitika muzvipfuwo uye huku.
Foregene
Literature Cited Products
RT Easy II (Master Premix yekutanga strand cDNA synthesis yeqPCR)
Catalog nhamba: RT-01031
Tsanangudzo: 25 × 20 μL rxns
Musoro wechinyorwa: Genetic diversity yeEchinococcus granulosus sensu lato muChina: Epidemiological zvidzidzo uye kurongeka kwekuongorora.
DOI: 10.1111/tbed.14469
Nguva yekuburitsa: 2022-2-9
Kudyidzana nemunyori: Sichuan Key Laboratory yeKurima neMhuka Genetic Resources Development uye Innovation
Abstract: Cystic echinococcosis (CE) chirwere chisina kutarisirwa chetropical zoonotic chinokonzerwa neEchinococcus granulosus uye chinoramba chiri dambudziko guru rehutano hwevanhu pasi rose.Iripo inozivikanwa genotypes yeEchinococcus granulosus kunze kweG4 yakaonekwa muChina, kunyanya Qinghai-Tibet Plateau, uye kusiyana kwavo kwemajini kwakasiyana munzvimbo ino yepasi.Maererano nekuongorora kwakarongeka, kuumbwa kwemajini eE. granulosa munyika yangu ndeyotevera: E. granulosa (G1, G3), 98.3%;Echinococcus intermedius (G5), 0.1%;Echinococcus intermedius (G6, G7), 1.4%;uye Canada Echinococcus (G8, G10), 0.2%.Kunyanya, huwandu hwehutachiona hweG1 hwaive 97.7% uye hwairatidzwa nehupamhi hwekugamuchira uye kugoverwa kwenzvimbo.Mhedzisiro yeEpidemiological yakaratidza kugadzikana uye kutsetseka kweE. coli gene muumbirwo muhwai uye yak kubva kumatunhu matatu eEC ane hutachiona hwepamusoro (Xinjiang, Sichuan, neQinghai).Makwai (287/406, 70.7%) aive nechikamu chepamusoro chema cysts akaorera kupfuura yak (28/184, 15.2%).Mumakore makumi maviri nemapfumbamwe apfuura, kwave ne51 Echinococcus granulosus cox1 haplotypes kuChina.The ancestral haplotype (Hap_2) yakaramba iri haplotype yakajairika, 12 haplotypes yakajairika yaive endemic, uye 9 ichangobva kutaurwa haplotypes yakaonekwa panguva yeongororo.Zvakawanikwa zvinoratidza kuti kudzvanywa kwegwai uye EG95 yekudzivirira mutyairi mushandirapamwe weyaks inonyatsoenderana neiyo genotype mamiriro.
Foregene
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Nguva yekutumira: Kubvumbi-08-2022
