Vatengi veChikoro cheHupenyu Sayenzi, Sichuan University yakaburitsa mapepa epamusoro-soro vachishandisa zvigadzirwa zveForegene, zvine chekuita ne17.848.

Nguva pfupi yadarika, timu yeSong Xu kubva kuChikoro cheHupenyu Sayenzi yeSichuan University yakaburitsa bepa rekuvhara rine musoro.Coagulation factor VII, IX uye X mapuroteni anorwisa mabhakitiriya anopesana nemishonga yeGram-negative Bacteria muCell Research.

Cell Research ibhuku repasi rose rakabatanidzwa pamwe chete neChinese Academy of Sciences neBritish Nature Publishing Group, iro rine chiremera munyika yezvidzidzo.

Pakangoburitswa chinyorwa ichi, chakabva chakonzera manyawi muzvidzidzo.Parizvino, mibairo yekutsvagisa yakagamuchirwa nevazhinji venhau seXinhua News Agency, World Wide Web, Phoenix Net, Southern Metropolis Daily,Biological Valley, British Daily Mail, American Daily Science, EurekAlert1!, Springer Nature, Phys.org, nezvimwewo., BioMedCentral nemamwe magazini anozivikanwa ane mishumo yakawanda, uye kutarisa kwepasi rose kune iyi tsvakurudzo yemigumisiro ichiri kukura.

Chinyorwa chakaratidza kuti matatu coagulation factor VII, IX uye X inobata basa mukutanga kweiyo coagulation cascade rudzi rutsva rwe endogenous host antibacterial protein, kureva, coagulation factor VII, IX uye X vane mabasa akakosha mukuita coagulation.Inogonawo kukwanisa kurwisa mabhakitiriya eGram-negative, kusanganisira "super bacteria" inopikisa zvikuru sePseudomonas aeruginosa uye Acinetobacter baumannii.

Song Xu, munyori anoenderana nechinyorwa ichi, akati: “Munguva yakapfuura, zvaiwanzotendwa kuti coagulation zvinhu zvinogona kukonzera thrombosis, asi chidzidzo ichi chakaratidza kuti coagulation zvinhu zvinewo kukosha kwekuita sterilization.Ichi ndicho chekutanga kuwanikwa kumba nekune dzimwe nyika.”

Zvekutsvagisa

Sezvatinoziva tese, kuramba kwebhakitiriya kwave dambudziko rehutano hweveruzhinji pasi rese.Mashoko akakodzera anoratidza kuti vanhu vangangosvika miriyoni imwe vanofa nehutachiona hwehutachiona hwehutachiona pasi rose gore rega rega.Kana pasina mhinduro iri nani, nhamba yevakafa gore rega rega kubva muna 2050 ichave mamirioni gumi.

Kushungurudzwa kwemishonga inorwisa mabhakitiriya, pamwe chete nehunyanzvi hwekushanduka-shanduka kwebhakitiriya, kwaita kuti mamwe mabhakitiriya epathogenic angadai akaurayiwa nemishonga inorwisa mabhakitiriya aite kurwisa zvinodhaka, achive "super bacteria" isingaparare.

Mukuwedzera, zvichienzaniswa neGram-positive bacteria (Gram +), mabhakitiriya asina kunaka (Gram-) anonyanya kuoma kuuraya nekuda kwekuvapo kwekunze membrane (chikamu chikuru iLPS, alias endotoxin, lipopolysaccharide).Iyo yekunze membrane ihamvuropu inoumbwa nemukati sero membrane, mutete sero madziro uye kunze kwesero membrane.

Nhoroondo yekutsvakurudza

Chikwata chaSong Xu chaive chiri kudzidza nezve mashandiro ezve coagulation pakurapa mabundu akaipa, asi muna 2009, zvakaonekwa zvisingatarisirwi kuti coagulation zvinhu zvinogona kuuraya mabhakitiriya.Kuti utsanangure nzira yebhaktericidal ye coagulation factor, chirongwa chave chiri makore gumi kubva pakutanga kwetsvagiridzo kusvika pakuburitswa kwebepa.

Zvakawanikwa netsaona

Muna 2009, vaongorori vakawana netsaona kuti coagulation factor VII inogona kurwisa Escherichia coli pakati pezvinodarika gumi nemaviri coagulation zvinhu.

Escherichia coli ndeye Gram-negative bacteria mubhakitiriya.Rudzi urwu rwebhakitiriya rwakaoma kubata narwo, nekuti masero avo ane membrane yemukati memukati, mutete rusvingo rwesero uye kunze kwesero membrane.Iyo envelopu inogona kuchengetedza mishonga kunze uye kudzivirira mabhakitiriya kubva "kupindira."

Propose assumption

Coagulation factor iboka remapuroteni ari muropa anobatanidzwa mukugwamba kweropa.Kana kukuvara kwemuviri wemunhu kuchikonzera kubuda ropa, zvakasiyana-siyana coagulation zvinhu zvinomisikidzwa nhanho nhanho kuita fibrin filaments, inosunga ronda pamwe chete nemaplatelet.Kana imwe kana akati wandei coagulation zvinhu zvisipo, coagulation kusagadzikana kunoitika.

Masayendisiti akacherechedza kuti varwere vane coagulopathy vanowanzotarisana nezvirwere zvebhakitiriya zvakadai sepsis uye pneumonia.Kubatana uku kwakaita kuti vafungidzire kuti coagulation zvinhu hazvingoite basa rakakosha mukuita coagulation, asi zvinogona zvakare kuve ne-anti-infection effect.

Kudzidza kwakadzama

Kuti uongorore kana coagulation zvinhu zvinogona kubata nehupamhi hwemhando yeGram-negative mabhakitiriya, vaongorori vakatanga kudzidza maitiro ayo antibacterial zvakadzama.Vakaona kuti coagulation factor VII uye yakarongeka yakafanana zvinhu IX uye factor X, mapuroteni matatu aya anogona kupaza nepakati pehamvuropu yakasimba yegiremu-negative mabhakitiriya.

Zvizhinji zviripo antibacterial zvinhu zvinonangana nesero metabolism kana maseru membrane, asi izvi zvitatu coagulation zvinhu zvine maitiro akasiyana ekuita.Vanogona hydrolyze LPS, chikamu chikuru chebhakitiriya rekunze membrane.Kurasikirwa neLPS kunoita kuti zviome kuti mabhakitiriya eGram-negative ararame.

Enda kumberi

Chikwata chekutsvagisa chakawedzera kuongorora magadzirirwo acho ndokuona kutiiyo coagulation factor protein inoshanda pabhakitiriya kuburikidza nechikamu chayo chetani, nepo chinorema cheni chikamu chisina antibacterial effect.

Munzvimbo yerabhoritari tsika, vatsvakurudzi vakanyatsocherechedza kuti mushure mekuwedzera coagulation factor kana kuti chiedza cheni chain components, bhakitiriya cell envelope yakatanga kukuvadzwa, uye mukati memaawa mana, yesero yebhakitiriya yakange yaparara zvachose.

Wedzera iyo factor VII mwenje cheni chikamu kune yakajairwa Escherichia coli,

Mabhakitiriya ekunze membrane zvikamu zvakakuvadzwa, masero anoparadzwa

Kwete Escherichia coli chete, asi mamwe mabhakitiriya eGram-negative akaedzwa "akakundwa", kusanganisira Pseudomonas aeruginosa uye Acinetobacter baumannii.Ose mabhakitiriya aya akanyorwa neWorld Health Organisation (WHO) semabhakitiriya gumi nemaviri ari kunyanya kutyisidzira hutano hwevanhu nekuda kwekusagadzikana kwemishonga.

Kuongorora kwekuongorora

Izvi zvinotevera zviedzo zvemhuka zvakasimbisa kushanda kwekuvhara zvinhu kurwisa mabhakitiriya makuru.

Vatsvakurudzi vakaisa mbeva nenhamba huru yePseudomonas aeruginosa kana Acinetobacter baumannii isingarapi zvinodhaka.Mushure mekuisa jekiseni yakakwira ye factor VII light chain, mbeva dzakapona;nepo mbeva dziri muboka rekutonga dzakabaiwa nesaline yakajairika dzaive 24 Vese vakafa nehutachiona mushure memaawa.

Mushure mekutapukirwa ne super bacteria, infusion ye factor VII light chain

Inogona kutamba basa rekudzivirira uye nekuvandudza zvakanyanya chiyero chekupona kwemakonzo

Kukosha

Parizvino, hapana antibacterial chinhu chinozivikanwa kuti chinoshanda ne hydrolyzing LPS.

Kujekesa nzira inorwisa mabhakitiriya yakavakirwa paLPS hydrolysis uye maitiro eantibacterial ezve coagulation zvinhu, zvakasanganiswa nekugona kuburitsa zvinhu izvi coagulation pamwero mukuru pamutengo wakaderera, zvinogona kupa inodhura-inoshanda nzira itsva yekurwisa zvinodhaka zvisingaite Gram-negative bhakitiriya Dambudziko rehutano hweveruzhinji rakatanga.

Pamusoro pezvo, basa iri rinewo tarisiro yakafara yekushandiswa mukuita kwekiriniki.Parizvino, hapana inozivikanwa mishonga inorwisa mabhakitiriya inoita mhedzisiro nehydrolyzing LPS.Kubatanidza antibacterial properties yeFVII, FIX, uye FX inopesana neLPS uye yakaderera-yakadhura-yakakura kugadzirwa, inotarisirwa kugadzira mishonga mitsva yekurwisa "super bacteria" zvirwere.

Topic extension

Kunyange zvazvo vanhu vachinyanya kujairana nezita rekuti “super bacteria”, izwi ravo rakarurama rinofanira kunge riri “multi-drug resistant bacteria”, iro rinoreva rudzi rwebhakitiriya rinopokana nemishonga yakawanda.

Sezvambotaurwa, kuwedzera kuri kuramba kuripo kwebhakitiriya kunonyanya kukonzerwa nekushandisa zvisina musoro kana kushungurudzwa kwemishonga inorwisa mabhakitiriya.Semuenzaniso, kushandiswa kwepamusoro-frequency ye-broad-spectrum antibiotics mukurapa kwezvirwere zvekufema.

Chirwere chechirwere chekufema chirwere chatinoziva tese.Maererano nenhamba, mwana mumwe nomumwe anotapukirwa kanenge ka6 kusvika ku9 pagore, uye vechidiki nevakuru vanotapukirwa ka2 kusvika ku4 pagore.

Nokuti zvirwere zvekufema zvinowanzova madhipatimendi ekukurumidzira, dambudziko guru kune vanachiremba vekukurumidzira pavanotarisana nevarwere nderekuti havagoni kuwana ruzivo rwepathogenic munguva pfupi.Naizvozvo, kunonoka kwekuongororwa kwepathogenic kunoita kuti varapi vashandise maantibioti akawanda (anogona kushanda).Kune marudzi mazhinji emabhakitiriya).

Iyi ndiyo nzira yekurapa “yekuparadzira mambure” ndiyo yakonzera dambudziko rinoramba richikura rokuramba utachiona hwemishonga.Nekuti kana twuzhinji hwemhando dzakasimba pahunoramba huchifa, mhando dzisingaite mushonga dzinowanda kutsiva dzinonzwa, uye kurwisa kwebhakitiriya kumushonga kucharamba kuchiwedzera.

Nokudaro, kana mushumo wakarurama wekuona pathogen unogona kuwanikwa munguva pfupi yekutungamira vanachiremba mukunyora mushonga wakakodzera, kushandiswa kwemishonga inorwisa mabhakitiriya yakawanda inogona kuderedzwa zvikuru, nokudaro kuderedza dambudziko rekudzivirira kwebhakitiriya.

Yakatarisana nedambudziko rinoshanda iri, timu yeFuji yesainzi yekutsvagisa yakatanga kugadzira 15-chinhu chekufema pathogen kit yekuongorora.

Kiti iyi inotora musanganiswa weDirect PCR uye multiplex PCR tekinoroji, inogona kuona Streptococcus pneumoniae, methicillin-resistant Staphylococcus aureus, Haemophilus influenzae uye mamwe gumi nemashanu akajairika ezasi ekufema maturakiti musputum munguva ingangoita 1 awa.Pathogenic mabhakitiriya anogona kunyatsosiyanisa pakati colonizing mabhakitiriya (yakajairika mabhakitiriya) uye pathogenic bacteria.Ndinotenda kuti zvichatarisirwa kuve chishandiso chinoshanda chekubatsira varapi mukushandiswa kwemishonga chaiko.

Pamberi pe "super bacteria", muvengi wepachena wevanhu vese, vanhu havana kumbozvitora kurerutsa.Mundima yesainzi yehupenyu, kuchine vaongorori vazhinji vakaita sechikwata chaSong Xu vari kushanda nesimba kuti vaongorore uye vashande chinyararire munzira kuti vawane mhinduro dze "super bacteria".

Pano, vakamiririra vezera ravo vezvakasikwa uye vanobatsirwa, Fortune Biotech inoda kuratidza ruremekedzo rwayo rwepamusoro kune vese vesainzi vakazvipira kuita uye dikita kune izvi, uye zvakare vanonamata kuti vanhu vagone kukunda "super bacteria" nekukurumidza uye vave nehupenyu hwakachengeteka uye hune hutano.zvakapoteredza.